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Epidemiological characteristics of human plague in the Sanjiangyuan region, Qinghai province, China, 1958-2021
JIANG Ke, XIONG Hao-ming, TIAN Fu-zhang, HE Duo-long, ZHANG Ai-ping, YANG Jian-guo, LI Xiang, GUO Wen-tao, LI Wei
Abstract78)      PDF (1475KB)(674)      
Objective To analyze the situation and characteristics of human plague epidemics in the Sanjiangyuan region, Qinghai province, China from 1958 to 2021, and to provide a scientific basis for formulating practical preventive measures against plague. Methods The data on human plague cases in the Sanjiangyuan region were collected from the human plague database of Qinghai Institute for Endemic Disease Control and Prevention. With Excel 2010, SPSS 26.0, and ArcMap 10.2 softwares, descriptive epidemiological methods were used to analyze the annual change, epidemic trend, seasonal distribution, regional distribution, population distribution, source of infection, route of transmission, and type of human plague in the Sanjiangyuan region. Results From 1958 to 2021, there were a total of 90 human plague epidemics in the Sanjiangyuan region, involving 253 cases and 138 deaths, with a mortality rate of 54.55% (138/253). There were 164 males and 89 females in all cases. Excluding four cases of unknown age, among the remaining 249 cases, young adults aged 16-30 years accounted for the highest proportion, which was 39.76% (99/249). The majority of the cases were Tibetan (205 cases). In occupational distribution, pastoralists accounted for 80.20% of the total cases. Human plague occurred during May to November, peaking in August. In the past 64 years of the Sanjiangyuan region, the situation of human plague was most serious in Yushu Tibetan Autonomous Prefecture, where Qumalai county had 15 outbreaks (48 cases), Yushu city had 15 outbreaks (41 cases), and Nangqian county had 12 outbreaks (37 cases). First cases were mainly caused by exposure to marmot infection through butchering and eating, followed by flea bites. Most first cases were bubonic plague (71 cases). Among all cases, pneumonic plague was the most common type, involving 161 cases (128 primary and 33 secondary cases). Conclusion The human plague situation in the Sanjiangyuan region remains unfavorable, which requires multiple preventive measures to effectively control human plague epidemics.
2022, 33 (6): 838-842.   doi: 10.11853/j.issn.1003.8280.2022.06.014
Discussion on Qinghai tourism and plague prevention and control
GUO Wen-tao, JIA Luo, FENG Jian-ping, WU Hai-sheng, ZHOU Kui-zhang, MI Bao-yu, ZHANG Qing-wen, MA Zhong-cheng, DAI Zhao, CHEN Zhi-zheng
Abstract350)      PDF (473KB)(876)      
With the rapid socioeconomic development, increasingly frequent personnel exchanges, and blossoming of tourism, a large number of people enter the natural plague foci for tourism and sightseeing, which greatly increases the chance of exposure to plague-infected animals and vector insects for floating populations. Once plague is transmitted to humans, it will be introduced into the urban areas within a very short period of time by modern means of transport such as airplanes, trains, and automobiles, which increases the risk of prompt transmission of plague. Qinghai province has the natural plague focus of Marmota himalayana which have spread across the province. Based on the tourism development and potential risk of plague in Qinghai province, it will assure and accelerate the healthy development of tourism to take corresponding prevention and control measures according to the practical situation of tourism.
2020, 31 (5): 630-632.    doi: 10.11853/j.issn.1003.8280.2020.05.026
Establishment and management of achieves on hosts and vectors in Marmota himalayana plague natural foci, Qinghai province
WAN Hui, WANG Xue, GUO Wen-tao, HE Jian, BAI Ji-xiang, LI Sheng, ZHOU Kui-zhang, MI Bao-yu, CHEN Hong-jian
Abstract251)      PDF (866KB)(745)      
Objective To better use achieves of hosts and vectors of Marmota himalayana plague natural foci in Qinghai province, and to provide convenient, fast, scientific and accurate information for prediction and prevention of plague epidemic in the future. Methods The mammals collected were made into taxidermy in general, part of the mammals were made into ecological modeling specimens. Fleas, mites, and ticks were made into mounting slides. All the specimens were registered for their collection information, and the specimen achieves were set up and preserved. Results A total of 30 420 specimens from the M. himalayana plague natural foci in Qinghai province were preserved in the Qinghai Endemic Control Institute, including mammals belonging to 6 orders, 26 families, 45 genera and 110 species. There are 174 species of 6 families, 43 genera of fleas, 12 species of ticks, 68 species from 16 families, 18 genera of sucking lice, as well as 123 species from 12 families, 35 genera of mites. Conclusion We collected, produced and preserved a large number of hosts and vectors related to plague epidemic in this epidemic area, which provided a scientific basis for the basic work of plague foci investigation and animal plague surveillance.
2018, 29 (5): 523-526.    doi: 10.11853/j.issn.1003.8280.2018.05.028
Evaluation on the growth of Yersinia pestis on 5 kinds of culture medias
FENG Jian-ping, GUO Wen-tao, YANG Jian-guo, LI Cun-xiang, ZHAO Hai-hong, JIN Xing, XIN You-quan, JIN Li-xia, XIONG Hao-ming, QI Zhi-zhen
Abstract277)      PDF (288KB)(880)      
Objective To observe the growth of Yersinia pestis on different kinds of culture media and screen for high quality culture media. Methods Make 5 kinds of culture media (Hiss Agar, Nutrient Agar, Sulfite Agar base, Hemolysis Agar Base, and Agar Hottinger nutrient)according to the instructions and pour into plates. Inoculating 0.1 ml Y. pestis suspensions on the prepared plate, calculating viable bacteria after 48-hour cultivation under 28℃ and observing the growth of Y. pestis on different culture media. Results There is no significant difference among Hiss Agar, Nutrient Agar and Sulfite Agar base. And the difference between Hemolysis Agar Base and Agar Hottinger nutrient was not significant either. The first three culture media and the following two culture media were also not significantly different. Hemolysis Agar Base and Agar Hottinger nutrient were superior to other culture media Hiss Agar, Nutrient Agar, Sulfite Agar base on growth of Y. pestis. Conclusion All the five culture media can be used for culture of Y. pestis, but Hemolysis Agar Base and Agar Hottinger nutrient were superior to the others.
2018, 29 (3): 303-304.    doi: 10.11853/j.issn.1003.8280.2018.03.022
Epidemic situation of plague in Qinghai section of the Qinghai-Tibet Railway, China: a 10-year analysis (2003-2013)
WU Hai-sheng, TIAN Fu-zhang, CHEN Hong-jian, GUO Wen-tao, WEI Rong-jie, XIONG Hao-ming, WANG Zu-yun
Abstract279)      PDF (866KB)(599)      

Objective To investigate the epidemic of plague in the past 10 years along the Qinghai-Tibet Railway, and to provide a scientific basis for the prevention and control of plague in future. Methods The monitoring results and clinical data for the human plague epidemic along the Qinghai-Tibet Railway from 2003 to 2013 were collected and analyzed using descriptive epidemiological methods. Results The emergence of plague in both animals and humans mainly occurred in the areas of Geermu (Tanggulashan Township), Tianjun, and Wulan in the Qinghai section of the Qinghai-Tibet Railway from 2003 to 2013. Sixty-nine strains of Yersinia pestis and 86 sera with positive F1 antibody were detected in these areas; 7 cases of human plague occurred, and 3 cases died. Conclusion Serious epidemic of plague remains in the Qinghai section of the Qinghai-Tibet Railway. Frequent occurrence of plague between animals and sporadic human plague epidemic are mainly related to illegal marmot hunting in these key areas.

2014, 25 (6): 561-563.    doi: 10.11853/j.issn.1003.4692.2014.06.020
Epidemic situation of plague in Qinghai section of the Qinghai-Tibet Railway, China: a 10-year analysis (2003-2013)
WU Hai-sheng, TIAN Fu-zhang, CHEN Hongjian, GUO Wen-tao, WEI Rong-jie, XIONG Hao-ming, WANG Zu-yun
Abstract197)      PDF (319KB)(532)      
Objective To investigate the epidemic of plague in the past 10 years along the Qinghai-Tibet Railway, and to provide a scientific basis for the prevention and control of plague in future. Methods The monitoring results and clinical data for the human plague epidemic along the Qinghai-Tibet Railway from 2003 to 2013 were collected and analyzed using descriptive epidemiological methods. Results The emergence of plague in both animals and humans mainly occurred in the areas of Geermu (Tanggulashan Township), Tianjun, and Wulan in the Qinghai section of the Qinghai-Tibet Railway from 2003 to 2013. Sixty-nine strains of Yersinia pestis and 86 sera with positive F1 antibody were detected in these areas; 7 cases of human plague occurred, and 3 cases died. Conclusion Serious epidemic of plague remains in the Qinghai section of the Qinghai-Tibet Railway. Frequent occurrence of plague between animals and sporadic human plague epidemic are mainly related to illegal marmot hunting in these key areas.
2014, 25 (6): 561-562.    doi: 10.11853/j.issn.1003.4692.2014.06.020
Palatability test of different baits to wild Marmota himalayana
GUO Wen-tao, CHEN Zhi-zheng, HU Guo-yuan, DU Peng-cheng, WU Hai-sheng, Jialuo, ZENG Cheng,CHEN Hong-jian, Gabuzang, WU Sheng-rong, ZHANG Yan-lai, AN Guo-qiang, ZHANG Run-de
Abstract275)      PDF (331KB)(931)      
2014, 25 (5): 477-478.    doi: 10.11853/j.issn.1003.4692.2014.05.027
Survey on soil-borne nematode infection in humans in Xining, China in 2012
LU Zhan-sheng, ZENG Cheng, GUO Wen-tao, DU Peng-cheng, JIA Luo
Abstract255)      PDF (273KB)(683)      
2014, 25 (4): 373-373.    doi: 10.11853/j.issn.1003.4692.2014.04.027
Analysis of serological surveillance data of plague in Yushu county, Qinghai province, 2004-2008
GUO Wen-tao, ZENG Cheng, JIA Luo, DU Peng-cheng, WU Hai-sheng, LU Zhan-sheng
Abstract465)      PDF (777KB)(705)      
2013, 24 (5): 472-472.    doi: 10.11853/j.issn.1003.4692.2013.05.029
Report of new species of chigger mites in Qinghai province: Distribution and type locality
WU Ke-Mei, WANG Xue, GUO Wen-Tao, WANG Yuan-Zhong
Abstract917)      PDF (300KB)(943)      
2010, 21 (2): 171-173.
Species and geographical distribution of carnivores and small mammals in Sanjiangyuan region
WANG Yuan-Zhong, LI Chao, WU Ke-Mei, WEI You-Wen, GUO Wen-Tao
Abstract1220)      PDF (311KB)(1051)      

【Abstract】 Objective To know the species and distributions of carnivores and small mammals in Sanjiangyuan area. Methods The investigation was done by the night trap. Results There were many carnivores and small mammals in San jiang yuan, belonging to 4 orders, 11 Familys, 27 Genera and 51 species. Conclusion Marmota himalayana, Microtus oeconomus, Mus musculus, Cricetulus longicaudatus, Ochotona curzoniae, Felis catus, Canis familiaris, Vulpes vulpes, Vulpes corsac, Canis upus,Mustela eversmanni distributed widely  in Sanjiangyuan Area. Marmota himalayana was the main host of nature plague foci in the Qinghai-Tibet plateau.

2009, 20 (6): 589-590.
A review on bacterium isolation from animals and vectors infected naturally by plague in Sanjiangyuan district
WU Ke-Mei, LI Chao, WANG Yuan-Zhong, WEI You-Wen, LUO Jun, GUO Wen-Tao, WU Hai-Sheng
Abstract1257)      PDF (380KB)(1144)      

【Abstract】 This paper briefly discusses the biology and ecological characteristics of host animals and vectors infected naturally by Yersinia pestis district and the time and location of first isolation in Sanjiangyuan. It is to understand the species of animals and vectors infected and the function they plays in the plague epidemiology in order to provide the basis for the prevention and control of plague in Sanjiangyuan.

2009, 20 (4): 365-368.